HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Oxalate → Ethyl benzo[g]quinazolin-4(3H)-one-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Oxalate | HCID 7268 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 3-aMino-2-naphthaMide | HCID 12471477 | — |
| Product | Ethyl benzo[g]quinazolin-4(3H)-one-2-carboxylate | HCID 135961510 | 79% |
Reaction Steps
Diethyl oxalate (2.35 g., 16.1 millimoles), sodium methoxide (10 mg) and 2-aminonaphthalene-3-carboxamide (1.50 g., 8.05 millimoles) are mixed together and heated at reflux for 2 days. The mixture is then cooled in an ice bath and the brown precipitate recovered by filtration. It is recrystallized from ethanol to give 1.76 g. (79% yield) of the desired ester. M.P. 240°-242°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03974161 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-30c246cdc7be461280909eb2da7dabc5 |
| Source note | uspto-grants-1976_08 |