HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl p-tolylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Methylbenzyl chloride | HCID 7722 | — |
| Reactant | Sodium Dithionite | HCID 24489 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Catalyst | Manganese | HCID 23930 | — |
| Product | Methyl p-tolylacetate | HCID 90265 | 57.2% |
| Product | p-Tolylacetic acid | HCID 248474 | 8% |
Reaction Steps
In the manner described in Example 1, 70.5 g (0.5 mole) of p-methylbenzyl chloride and 135 g of a 24 wt-% sodium methylate solution in methanol, 5 g CoCl2. 6 H2O, 4 g manganese powder and 1 g sodium dithionite were reacted with CO. The reaction and the processing were performed as described in Example 1. 47.0 g of p-methylphenylacetic acid methyl ester (BP13 113°) (yield 57.2%) was isolated in a purity of 98%, plus 6.2 of p-methylphenylacetic acid (MP 89°-90°C, yield 8%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03974202 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-624af697f1f54a95bed0a35c94e180fc |
| Source note | uspto-grants-1976_08 |