Water → HCID 21418271, compound

HRID 1283200Notes

Reaction equation

HRID 1283200 reaction equation
[Cl:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[C:3]=1[CH2:20][C:21](N)=[O:22].N([O-])=[O:25].[Na+].O>S(=O)(=O)(O)O>[Cl:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[C:3]=1[CH2:20][C:21]([OH:22])=[O:25]

Participants

5

Reactant 3

HCID 962WaterHCID 23668193Sodium NitriteHCID 53741545HCID 53741545, compound

Product 1

HCID 21418271HCID 21418271, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

3.5 g of 5-chloro-3-p-chlorophenyl-1-phenyl-pyrazole-4-acetamide are dissolved in 15 ml of 90 % sulfuric acid and while stirring at 20° to 30° a solution of 0.7 g sodium nitrite in a little water is passed dropwise under the surface. Gentle heating is carried out until the evolution of gas is terminated and the mixture is then poured on to an ice and water mixture. 5-Chloro-3-p-chlorophenyl-1-phenyl-pyrazole-4-acetic acid is produced; F 179.5°-181°.

Workup

  1. temperatureGentle heating
  2. customis terminated
  3. additionthe mixture is then poured on to an ice and water mixture

Sources & evidence

ORD record
ord-416757aa8b0b42afbc9eff37b4b7dff0
Source dataset
uspto-grants-1976_08
Patent number
US03974176

Reaction notes

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