HuagongsheHuagongshe Chemistry Print Report · For research reference only
P-Chloroacetophenone → 5-Chloro-3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | P-Chloroacetophenone | HCID 7467 | — |
| Reactant | Phenylhydrazine | HCID 7516 | — |
| Reactant | Diethyl Carbonate | HCID 7766 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Ethyl 3-(4-chlorophenyl)-3-oxopropanoate | HCID 101336 | — |
| Reactant | 3-(4-Chlorophenyl)-1-phenyl-2-pyrazolin-5-one | HCID 10286088 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Chloro-3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde | HCID 21418360 | — |
Reaction Steps
50.8 g of ethyl p-chlorobenzoylacetate (produced for example from p-chloroacetophenone, diethyl carbonate and sodium hydride with a yield of 72%), 24 g of phenylhydrazine, 5 ml of glacial acetic acid and 150 ml of ethanol are heated in a nitrogen atmosphere for 1 hour at boiling point. After cooling in an ice bath 3-p-chlorophenyl-1-phenyl-2-pyrazoline-5-one is obtained with a yield of 84 %; F 160.5°-161.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03974176 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-1d069b82fd4749a4bc4236a4f307ac34 |
| Source note | uspto-grants-1976_08 |