HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylene-2',3'-dichloro-4'-methoxypropiophenone → 2-Methyl-5-methoxy-6,7-dichloro-1-indanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylene-2',3'-dichloro-4'-methoxypropiophenone | HCID 12395560 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 2-Methyl-5-methoxy-6,7-dichloro-1-indanone | HCID 12395561 | — |
Reaction Steps
A solution of 2-methylene-2',3'-dichloro-4'-methoxypropiophenone (40 g., 0.163 mole) in concentrated sulfuric acid (75 ml.) is allowed to stand at 25°C. for 24 hours and then is slowly poured into vigorously stirred ice water (500 ml.). The 2-methyl-5-methoxy-6,7-dichloro-1-indanone (VI) which separate (40 mg.) melts at 129°C. after recrystallization from methylcyclohexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03974212 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-c16675bd74fc4e42a66eda1472ac12ca |
| Source note | uspto-grants-1976_08 |