Methyl iodide → HCID 12395564, compound

Participants

Reaction Conditions

Reaction Steps

A stirred suspension of 2-isopropyl-5-methoxy-6,7-dichloro-1-indanone (7.3 g., 0.025 mole) and sodium hydride (810 mg., 0.028 mole) in anhydrous 1,2-dimethoxyethane (250 ml.) is heated in an inert atmosphere at 80°-85°C. for 1 hour, cooled to 30°C. and treated with methyl iodide (6 ml.). The reaction mixture is heated to 80°C. then the solvent is distilled at reduced pressure and the residue poured into ice water. The 2-methyl-2-isopropyl-5-methoxy-6,7-dichloro-1-indanone which separates (7.0 g.) melts at 143°C. after recrystallization from ethanol-water.

Provenance & Evidence