HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzaldehyde → HCID 68120616, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzaldehyde | HCID 6996 | — |
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Reactant | Ethyl 4-ethoxy-3-oxobutyrate | HCID 3016245 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 68120616 | HCID 68120616 | 55% |
Reaction Steps
After heating a solution of 14 g of 2-chlorobenzaldehyde, 17.4 g of γ-ethoxyacetoacetic acid ethyl ester and 13 g of β-aminocrotonic acid ethyl ester in 80 ml of ethanol under reflux for several hours, 2-ethoxymethyl-6-methyl-4-(2'-chlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester is obtained, after cooling, in the form of light yellow crystals of melting point 115°C, in a yield of 55% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03974278 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-a0e407004c7f4241a4be3cebb121fb21 |
| Source note | uspto-grants-1976_08 |