HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-p-anisaldehyde → HCID 68120912, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-p-anisaldehyde | HCID 67696 | — |
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Reactant | Ethyl 4-ethoxy-3-oxobutyrate | HCID 3016245 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 68120912 | HCID 68120912 | 35% |
Reaction Steps
15.4 g of 3-fluoro-4-methoxybenzaldehyde, 17.4 g of γ-ethoxyacetoacetic acid ethyl ester and 13 g of β-aminocrotonic acid ethyl ester in 80 ml of ethanol are heated to the boil overnight, the mixture is cooled, and after filtration and rinsing with cold ethanol, 2-ethoxymethyl-6-methyl-4-(3'-fluoro-4'-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester is obtained in 35% yield of theory, in the form of white crystals of melting point 120°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03974278 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-53daa6356d3d468ea9d13d925db46b0d |
| Source note | uspto-grants-1976_08 |