HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Methylsulfonyl)benzaldehyde → 2-Methoxymethyl-6-methyl-4-(4'-methylsulphonylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Methylsulfonyl)benzaldehyde | HCID 220376 | — |
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Reactant | Ethyl 4-methoxy-3-oxobutanoate | HCID 12645099 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Methoxymethyl-6-methyl-4-(4'-methylsulphonylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 68121017 | 65% |
Reaction Steps
A solution of 9.2 g of 4-methylsulphonylbenzaldehyde, 8 g of γ-methoxyacetoacetic acid ethyl ester and 6.5 g of β-aminocrotonic acid ethyl ester in 40 ml of ethanol is heated to the boil and, after cooling, 2-methoxymethyl-6-methyl-4-(4'-methylsulphonylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester is obtained in the form of yellow crystals of melting point 156°-158°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03974278 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-c4a94212307643d4a19a8927daeaaf68 |
| Source note | uspto-grants-1976_08 |