HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2,6-Dimethoxymethyl-4-(4'-methylmercaptophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-(Methylthio)benzaldehyde | HCID 76985 | — |
| Reactant | Ethyl 4-methoxy-3-oxobutanoate | HCID 12645099 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,6-Dimethoxymethyl-4-(4'-methylmercaptophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 68121248 | 50% |
Reaction Steps
7.6 g of 4-methylmercaptobenzaldehyde, 16 g of γ-methoxyacetoacetic acid ethyl ester and 6 ml of aqueous concentrated ammonia in 30 ml of ethanol are heated to the boil for 6-8 hours, and 2,6-dimethoxymethyl-4-(4'-methylmercaptophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester is obtained in the form of beige crystals of melting point 136°-138°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03974278 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-b8fa68da08ea436b99ba38346b7d6df2 |
| Source note | uspto-grants-1976_08 |