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Water → 1-(1-Hydroxy-1-methoxycarbonylmethyl)-3-(triphenyl methylamino)-4-(3-phenylprop-2-ynylthio)azetidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Acetic acid, 2-oxo-, methyl ester | HCID 70205 | — |
| 反応物 | 3-(Triphenylmethylamino)-4-(3-phenylprop-2-ynylthio)azetidin-2-one | HCID 21519177 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 1-(1-Hydroxy-1-methoxycarbonylmethyl)-3-(triphenyl methylamino)-4-(3-phenylprop-2-ynylthio)azetidin-2-one | HCID 53714964 | 64% |
反応手順
3-(Triphenylmethylamino)-4-(3-phenylprop-2-ynylthio)azetidin-2-one (526mg) and methyl glyoxylate (1.17g) were refluxed in dry benzene (25ml) with provision for the removal of water. After 11/2 hours the solvent was evaporated and the residue was chromatographed on silica to give 1-(1-hydroxy-1-methoxycarbonylmethyl)-3-(triphenyl methylamino)-4-(3-phenylprop-2-ynylthio)azetidin-2-one as an amorphous solid (399 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03974154 |
| 出典データセット | uspto-grants-1976_08 |
| ORD ID | ord-8d5f34d2222e4435899979fac1795ac4 |
| 出典メモ | uspto-grants-1976_08 |