反应详情

3.08 gm (0.014 mol) of 4-chloro-6-amino-2-methylthio-5-nitro-pyrimidine were dissolved in 50 ml of acetone, and a solution of 3.2 gm (0.027 mol) of thiomorpholine-1-oxide in 20 ml of acetone was added dropwise at room temperature, while stirring. After stirring the mixture for 1.5 hours more, ice was added to the reaction mixture, and the yellow precipitate formed thereby was suction-filtered off and recrystallized from ethanol. Yield: 78.2% of theory; m.p. 239°-242°C.

1. stirringAfter stirring the mixture for 1.5 hours more
2. additionice was added to the reaction mixture
3. customthe yellow precipitate formed
4. filtrationthereby was suction-filtered off
5. customrecrystallized from ethanol