Piperazine → HCID 53696522, compound

Participants

Reaction Steps

1.8 gm (0.005 mol) of 5-chloro-6-cyano-4-(1,1-dioxido-thiomorpholino)-2-ethylsulfonyl-pyrimidine (m.p. 234°-237°C, obtained from 2-ethylthio-5-chloro-6-cyano-4-thiomorpholino-pyrimidine by oxidation with potassium permanganate in dilute hydrochloric acid) were slowly added to a solution of 2.6 gm (0.03 mol) of piperazine in 50 ml of dioxane. After standing for a short time, the reaction solution was evaporated almost to dryness in vacuo, and the residue was taken up in about 50 ml of water. The insoluble reaction product was suction-filtered off, washed with water and dried. Yield: 1.4 gm (78% of theory).

Provenance & Evidence