Thiomorpholine 1-oxide → HCID 54161598, compound

Participants

Reaction Steps

0.3 gm (0.001 mol) of 5-chloro-6-cyano-4-phenoxy-2-piperazino-pyrimidine [m.p. 126°-128°C, obtained from 6-cyano-2,5-dichloro-4-phenoxy-pyrimidine and piperazine in acetone/dioxane (1:1) while cooling] were heated with 2.3 gm (0.02 mol) of thiomorpholine-1-oxide at about 140°C for 90 minutes. The dark colored molten mass was taken up in a small quantity of water, and the precipitated raw reaction product was purified on a silicagel column [eluant: methanol/concentrated ammonia (8:1)]. After reprecipitation from 0.2 N hydrochloric acid with ammonia, 5-chloro-6-cyano-2-piperazino-4-(1-oxido-thiomorpholino)-pyrimidine, m.p. 206°-208°C, was obtained.

Provenance & Evidence