Water → HCID 53937887, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 0.8 gm (0.005 mol) of potassium permanganate in 30 ml of water was slowly added dropwise to a solution of 1.6 gm (0.005 mol) of 6-methyl-5-nitro-2-piperazino-4-thiomorpholino-pyrimidine (m.p. 141°-142°C) in about 60 ml of 0.5 N hydrochloric acid at about 5°C. After stirring the reaction mixture for 1 hour at about 5°C, the precipitated manganese dioxide was removed by means of a sodium bisulfite solution. The reaction product was precipitated by addition of concentrated ammonia, washed with water and dried (m.p. 208°-211°C). Yield: 1.4 gm (79% of theory).

Provenance & Evidence