Water → HCID 53714502, compound

Participants

Reaction Steps

2.0 gm (0.006 mol) of 5-carbethoxy-2-chloro-4-(1,1-dioxido-thiomorpholino)-6-methyl-pyrimidine were added in small portions to a boiling solution of 5.2 gm (0.06 mol) of piperazine in 70 ml of dioxane, and the mixture was refluxed for 20 minutes. The reaction mixture was then poured into 150 ml of water, and the aqueous mixture was extracted with chloroform. The organic extract was washed with water, dried with sodium sulfate, and the solvent was removed in vacuo. The residue was recrystallized from ethanol/petroleum ether. Yield: 1.7 gm (74% of theory); m.p. 154°-159°C.

Provenance & Evidence