HCID 21517701, compound → HCID 54433626, compound

HRID 1283470Notes

Reaction equation

HRID 1283470 reaction equation
[CH2:1]([O:3][C:4]1[N:9]=[C:8]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[N:7]=[C:6]([N:16]2[CH2:21][CH2:20][S:19][CH2:18][CH2:17]2)[C:5]=1[N+:22]([O-:24])=[O:23])[CH3:2].I([O-])(=O)(=O)=[O:26].[Na+]>CO.O>[CH2:1]([O:3][C:4]1[N:9]=[C:8]([N:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)[N:7]=[C:6]([N:16]2[CH2:17][CH2:18][S:19](=[O:26])[CH2:20][CH2:21]2)[C:5]=1[N+:22]([O-:24])=[O:23])[CH3:2]

Participants

5

Reactant 2

HCID 21517701HCID 21517701, compoundHCID 23667635Sodium periodate

Product 1

HCID 54433626HCID 54433626, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent2×

Procedure

3.6 gm (0.01 mol) of 6-ethoxy-5-nitro-2-piperazino-4-thiomorpholino-pyrimidine were dissolved in 100 ml of methanol, a solution of 2.2 gm (0.01 mol) of sodium metaperiodate in 50 ml of water was added, and the mixture was refluxed for 4 hours. The reaction mixture was then poured into water, and the aqueous mixture was extracted with chloroform. The chloroform phase was dried, the chloroform was distilled off in vacuo, and the residue was recrystallized from ethanol. Yield: 2.9 gm (77% of theory); m.p. 223°-224°C.

Workup

  1. temperaturethe mixture was refluxed for 4 hours
  2. extractionthe aqueous mixture was extracted with chloroform
  3. dry with materialThe chloroform phase was dried
  4. distillationthe chloroform was distilled off in vacuo
  5. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-0e33a7b45a0d4bc4bafd7af5bb27252a
Source dataset
uspto-grants-1976_08
Patent number
US03975384

Reaction notes

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