Hydrochloric Acid → HCID 53693672, compound

Participants

Reaction Steps

4.5 gm (0.011 mol) of 6-neopentyloxy-5-nitro-2-piperazino-4-thiomorpholino-pyrimidine were suspended in a mixture of 60 ml of water and 11.4 ml (0.022 mol) of 2 N hydrochloric acid. 1.66 gm (0.011 mol) of 30% hydrogen peroxide were added to the suspension, and the mixture was stirred for 24 hours at room temperature, whereby a clear solution was obtained. The solution was made alkaline by careful addition of 12 ml of 2 N sodium hydroxide, and the yellow precipitate formed thereby was suction-filtered off, washed with water and recrystallized from a mixture of 30 ml of methanol and 20 ml of water. Yield: 2.4 gm (51.2% of theory); m.p. 156°-158°C.

Provenance & Evidence