Ethanol → HCID 21517759, compound

Participants

Reaction Steps

3.0 gm (9.3 millimols) of 6-chloro-2-methylthio-5-nitro-4-(1-oxido-thiomorpholino)-pyrimidine (m.p. 128°-131°C) were added at room temperature to a sodium ethylate solution prepared from 0.22 gm (9.4 millimols) of sodium and 30 ml of ethanol, and the mixture was refluxed for 2 hours. After standing for 20 hours at room temperature, the reaction mixture was poured into water, the aqueous mixture was extracted several times with chloroform/ethanol, the combined extract solutions were evaporated to dryness, and the residue was recrystallized from ethyl acetate/petroleum ether. Yield: 2 gm (65% of theory); m.p. 130°-132°C.

Provenance & Evidence