Nitric Acid → HCID 54433626, compound

Participants

Reaction Conditions

Reaction Steps

1 gm of 6-ethoxy- 2-piperazino-4-thiomorpholino-pyrimidine was added to 3 ml of concentrated sulfuric acid, whereby the temperature of the resulting suspension rose to 50°C. After cooling to 0°C, 2 ml of concentrated nitric acid were added dropwise while stirring. After stirring it for another hour at room temperature, the reaction mixture was filtered through glass wool, and the filtrate was stirred into ice water. By careful addition of aqueous 40% sodium hydroxide, the mixture was adjusted to pH 9 and extracted with chloroform. The chloroform phase was washed with water, dried with sodium sulfate, and the solvent was distilled off in vacuo. The residue was recrystallized from ethanol. Yield: 0.8 gm (66.9% of theory); m.p. 223°-224°C.

Provenance & Evidence