Succinic anhydride → HCID 53757176, compound

HRID 1283476Notes

Reaction equation

HRID 1283476 reaction equation
[CH2:1]([O:3][C:4]1[N:9]=[C:8]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[N:7]=[C:6]([N:16]2[CH2:21][CH2:20][S:19](=[O:22])[CH2:18][CH2:17]2)[C:5]=1[N+:23]([O-:25])=[O:24])[CH3:2].[C:26]1(=[O:32])[O:31][C:29](=[O:30])[CH2:28][CH2:27]1>O1CCOCC1>[CH2:1]([O:3][C:4]1[N:9]=[C:8]([N:10]2[CH2:11][CH2:12][N:13]([C:26](=[O:32])[CH2:27][CH2:28][C:29]([OH:31])=[O:30])[CH2:14][CH2:15]2)[N:7]=[C:6]([N:16]2[CH2:17][CH2:18][S:19](=[O:22])[CH2:20][CH2:21]2)[C:5]=1[N+:23]([O-:25])=[O:24])[CH3:2]

Participants

4

Reactant 2

HCID 7922Succinic anhydrideHCID 54433626HCID 54433626, compound

Product 1

HCID 53757176HCID 53757176, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3.75 gm (0.01 mol) of 6-ethoxy-5-nitro-4-(1-oxido-thiomorpholino)-2-piperazino-pyrimidine (m.p. 223°-224°C) were refluxed together with 2.0 gm (0.02 mol) of freshly distilled succinic acid anhydride in 50 ml of dioxane for 1 hour. The reaction solution was then evaporated to dryness, and the solid residue was recrystallized from ethyl acetate/isopropanol. Yield: 2.0 gm (42.5% of theory); m.p. 198°-200°C.

Workup

  1. customThe reaction solution was then evaporated to dryness
  2. customthe solid residue was recrystallized from ethyl acetate/isopropanol

Sources & evidence

ORD record
ord-098ae315554342ccb3fcc39ac54b195c
Source dataset
uspto-grants-1976_08
Patent number
US03975384

Reaction notes

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