Acetic Acid → Pga1

Participants

Reaction Conditions

Reaction Steps

Refer to Chart E, wherein E is --CH=CH--, R2 is methyl, R4 is hydrogen, V is --(CH2)5 --, and W is 1-pentyl. A mixture of PGE1, 15-methyl ether, (0.4 g.), glacial acetic acid (9 ml.), and water (1 ml.) is heated under nitrogen at 60° C. for 18 hrs. The mixture is concentrated under reduced pressure, and the residue is subjected to silica gel chromatography, eluting with 25-100% ethyl acetate-Skellysolve B. The fractions shown by TLC to contain the desired product free of starting material and impurities are combined and concentrated to give the Formula-X PGA1 -type title compound.

Provenance & Evidence