反应详情

A solution of 6.0 g. of potassium hydroxide, 6 ml. of water and 60 ml. of methanol is added to the ethyl 2-(6-methoxy-2-naphthyl)propionate, and the mixture is heated at reflux for 45 minutes, cooled to ambient temperature, acidified and mixed with 60 ml. of water. Methanol is removed by evaporation in vacuo, and the resultant solution is extracted with two 60 ml. portions of methylene chloride. The combined methylene chloride extracts are evaporated to dryness to yield 2-(6-methoxy-2-naphthyl)propionic acid.

1. temperaturethe mixture is heated
2. temperatureat reflux for 45 minutes
3. additionmixed with 60 ml
4. customMethanol is removed by evaporation in vacuo
5. extractionthe resultant solution is extracted with two 60 ml
6. customThe combined methylene chloride extracts are evaporated to dryness