Methanol → HCID 21518340, compound

Participants

Reaction Steps

A solution of 2-(5-oxo-10,11-dihydrodibenzo[a,d]cyclohepten-2-yl)propionyl chloride (10 g.) in methylene chloride (100 cc.) is added at 20°C. and over the course of 10 minutes to a mixture of methanol (100 cc.) and anhydrous pyridine (10 cc.). On concentrating the reaction mixture to dryness, a paste-like residue (weighing 14 g.) is obtained and the latter is taken up in diethyl ether (500 c.) and water (100 cc.). The ether phase is decanted, washed twice with water (total 100 cc.) and dried over potassium carbonate. On concentrating to dryness, methyl 2-(5-oxo-10,11-dihydrodibenzo[a,d]cyclohepten-2-yl)propionate (8.6 g.) is obtained.

Provenance & Evidence