Benzoyl chloride, 3,4-dichloro- → AH 7921 hydrochloride

HRID 1283523Notes

Reaction equation

HRID 1283523 reaction equation
[NH2:1][CH2:2][C:3]1([N:9]([CH3:11])[CH3:10])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[Cl:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=1[Cl:22])[C:16](Cl)=[O:17]>N1C=CC=CC=1>[ClH:12].[Cl:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=1[Cl:22])[C:16]([NH:1][CH2:2][C:3]1([N:9]([CH3:11])[CH3:10])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1)=[O:17]

Participants

4

Reactant 2

HCID 76403Benzoyl chloride, 3,4-dichloro-HCID 21134031-(Aminomethyl)-N,N-dimethylcyclohexan-1-amine

Product 1

HCID 21409948AH 7921 hydrochloride

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 1-aminomethylcyclohexyl dimethylamine (1.0 g.), 3,4-dichlorobenzoyl chloride (2 ml) and pyridine (10 ml) was allowed to stand at room temp. for 1 hr. The pale yellow solid produced was filtered and recrystallised from ethanol/ether to give a colourless microneedles of 1-(3,4-dichlorobenzamidomethyl)-cyclohexyldimethylamine hydrochloride m.p. 215°-16° .

Workup

  1. customThe pale yellow solid produced
  2. filtrationwas filtered
  3. customrecrystallised from ethanol/ether

Sources & evidence

ORD record
ord-43c3332645cb4b1ebb07d1e1bd2d4821
Source dataset
uspto-grants-1976_08
Patent number
US03975443

Reaction notes

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