HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzoyl chloride → N-{[1-(Dimethylamino)cyclohexyl]methyl}-4-fluorobenzamide hydrochloride (1:1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzoyl chloride | HCID 67879 | — |
| Reactant | 1-(Aminomethyl)-N,N-dimethylcyclohexan-1-amine | HCID 2113403 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-{[1-(Dimethylamino)cyclohexyl]methyl}-4-fluorobenzamide hydrochloride (1:1) | HCID 21409921 | — |
Reaction Steps
A mixture of 1-aminomethylcyclohexyldimethylamine (1.0 g), 4-fluorobenzoyl chloride (2 ml) and pyridine (10 ml) was allowed to stand at room temperature for 1 hr. The crystalline material produced was filtered and recrystallised several times from ethanol/ether to give colourless needles of 1-(4-fluorobenzamidomethyl)-cyclohexyl dimethylamine hydrochloride m.p. 238°-239° .
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03975443 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-7dad90d3f0d24c97baab3dc92b04ff79 |
| Source note | uspto-grants-1976_08 |