Ammonia → HCID 86733841, compound

Participants

Reaction Steps

A mixture of 1-(1-aminomethylcyclohexyl) piperidine (1.5 g.), 2-chlorobenzoyl chloride (2 ml) and pyridine (10 ml) was allowed to stand at room temperature for 1 hr. with no apparent effect. The mixture was therefore refluxed for 1 hr., cooled, diluted with water, basified with ammonia and extracted with chloroform. This chloroform extract was washed with water, dried (Na2SO4), and evaporated to give a viscous, brown oil (3.0 g. 79.2%). On dissolving in ether and bubbling dry HCl gas into the solution pale buff rosettes of 1-(2-chlorobenzamidomethylcyclohexyl) piperidine hydrochloride, m.p. 234°-6° were obtained (from -ethanol/ether.

Provenance & Evidence