Benzoyl chloride, 3,4,5-trimethoxy- → HCID 21409951, compound

Participants

Reaction Steps

A solution of 3,4,5-trimethoxybenzoyl chloride (2.2 g;) in dry benzene (25 ml) and a solution of 1-[1-(aminomethyl)cyclohexyl]-4-methyl piperazine (2.0g;) in dry benzene (25 ml) were mixed and heated under reflux for 1 hr. The solid which formed was filtered, washed with benzene and was recrystallised from isopropanol-ether to give 1-[1-(3,4,5-trimethoxybenzamidomethyl)cyclohexyl]-4-methyl piperazine hydrochloride (1.9 g., 45.4%) m.p. 208°-9°C.

Provenance & Evidence