Water → HCID 21409899, compound

Participants

Reaction Steps

To a stirred solution of lithium aluminium hydride (3 g.,) in dry tetrahydrofuran (40 ml) was added a solution of 1-[1-(Acetamidomethyl)cyclohexyl]-4-methyl piperazine (3 g.,) in dry tetrahydrofuran (40 ml) dropwise. The stirring was continued overnight, the suspension was heated under reflux for a further 6 hrs. and the excess LiAlH4 neutralised with water. The mixture was filtered and the filtrate was dried (anhyd. Na2SO4) and evaporated to an oil, which was micro distilled to give 1-[1-(Ethylaminomethyl)cyclohexyl]-4-methyl piperazine as a colourless oil. b.p. 35mm 105°-109° (1.96 g., 69%)

Provenance & Evidence