HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyano-2,3-dimethylisothiourea → HCID 178484954, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyano-2,3-dimethylisothiourea | HCID 111103 | — |
| Reactant | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| Reactant | 4-(1,3-Thiazol-2-yl)butan-1-amine | HCID 17931257 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 178484954 | HCID 178484954 | — |
Reaction Steps
A solution of 2-(4-aminobutyl)thiazole (from the dihydrochloride 13.8 g.) and N-cyano-N', S-dimethylisothiourea (7.75 g) in acetonitrile was heated under reflux for 24 hours. Following concentration, the residue was chromatographed on a column of silica gel with acetonitrile as eluant and the product obtained was recrystallised from isopropyl alcohol-isopropyl acetate to yield N-cyano-N'-methyl-N"-[4-(2-thiazolyl)butyl]guanidine m.p. 87°-89.5°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03975530 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-0da9829688864425ad5b9cb3b2862a71 |
| Source note | uspto-grants-1976_08 |