Hydrogen Peroxide → HCID 21655744, compound

Participants

Reaction Steps

8.4 gm (0.086 mol) of 34.8% hydrogen peroxide were added dropwise to a suspension of 28.5 gm (0.078 mol) of 1-thiomorpholino-3-piperazino-5-methyl-isoquinoline hydrochloride in 160 ml of 2 N sulfuric acid at 0°C, and the mixture was stirred for 2 hours at 15°-20°C. The mixture was then made alkaline with concentrated sodium hydroxide and exhaustively extracted with a mixture of chloroform and ethanol (3:1). The organic phase was isolated, washed with water and sodium chloride solution, dried and evaporated, and the residue was recrystallized from 150 ml of isopropanol. Yield: 11.6 gm (43% of theory); m.p. 201°-203°C.

Provenance & Evidence