2-Formyl-5-methoxybenzoic acid → 7-Methoxyisocoumarin-3-carboxylic acid

HRID 1283599Notes

Reaction equation

HRID 1283599 reaction equation
[C:1]([C:4]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:5]=1[CH:6]=O)([OH:3])=[O:2]>CCO>[CH3:13][O:12][C:10]1[CH:11]=[C:4]2[C:5]([CH:6]=[C:4]([C:1]([OH:3])=[O:2])[O:3][C:1]2=[O:2])=[CH:8][CH:9]=1

Participants

3

Reactant 1

HCID 71762052-Formyl-5-methoxybenzoic acid

Product 1

HCID 214236777-Methoxyisocoumarin-3-carboxylic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

7-Methoxyisocoumarin-3-carboxylic acid, mp. (EtOH) 280°-3°, (Found: C, 60.11; H, 3.93. C11H8O5 requires C, 60.00; H, 3.66) was prepared from 2-carboxy-4-methoxybenzaldehyde by an analogous procedure to that described in Example 1.

Sources & evidence

ORD record
ord-3cc1b14dd9f2463e91cda7c30574311a
Source dataset
uspto-grants-1976_08
Patent number
US03975535

Reaction notes

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