HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-Oxo-1,2-dihydroisoquinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-oxo-1H-isochromene-3-carboxylic acid | HCID 345561 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-Oxo-1,2-dihydroisoquinoline-3-carboxylic acid | HCID 280001 | — |
Reaction Steps
Isocoumarin-3-carboxylic acid (1.40g.) was added to a solution of ammonia (d. 0.88, 10ml.) in ethanol (40ml.) at 0° and allowed to stand for 24 hours. After removal of solvent in vacuo, 6N hydrochloric acid (70ml.) was added and allowed to stand for 1 hour at 0°. Filtration gave the product as a white solid, mp. 327°-330° (lit mp. 326°-8°), (Found: C, 62.91; H, 3.69; N, 7.46. C10H7NO3 requires C, 63.49; H, 3.73; N, 7.40).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03975535 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-3121e27e966e4d369d482e6711d1ffbc |
| Source note | uspto-grants-1976_08 |