2-Aminobenzophenone → HCID 21518534, compound

Participants

Reaction Steps

In process (c) a solution of a selected aminobenzophenone (X) in a halogenated organic solvent, e.g., methylene chloride, is treated at -50° to -78°C. with t-butylhypochlorite and then with a lower alkyl α-(methylthio)acetate as, for example, ethyl α-(methylthio)acetate to give an ethyl 2-amino-3-(5- or 7-) benzoyl-α-(methylthio)acetate (XI) which can be isolated or can be converted in situ by the addition of a dilute mineral acid such as dilute hydrochloric acid to a 3-methylthio-4-(5- or 7-) benzolindolin-2-one (XII). The 3-methylthio group is removed by stirring a dry tetrahydrofuran solution of the 3-methylthio compound (XII) with Raney-Ni under an inert gas to give a benzoylindolin-2-one of Formula I.

Provenance & Evidence