2-Butylbenzofuran → HCID 21518601, compound

HRID 1283642Notes

Reaction equation

[CH2:1]([C:5]1[O:6][C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[CH:9]=1)[CH2:2][CH2:3][CH3:4].[Cl:14][C:15]1[CH:23]=[C:22]([O:24][CH3:25])[CH:21]=[CH:20][C:16]=1[C:17](Cl)=[O:18]>>[CH2:1]([C:5]1[O:6][C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[C:9]=1[C:17](=[O:18])[C:16]1[CH:20]=[CH:21][C:22]([O:24][CH3:25])=[CH:23][C:15]=1[Cl:14])[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 779512-Butylbenzofuran

HCID 144847152-Chloro-4-methoxybenzoyl chloride

Product 1

HCID 21518601HCID 21518601, compound

Procedure

2-n-Butylbezofuran (5.7 g., 0.033 mol.) was acylated with 6.7 g. (0.033 mol.) of 2-chloro-4-methoxybenzoic acid chloride in the presence of 18 g. (0.07 mol.) of stannic chloride as described in the procedure of Example 10 to give 2-n-butyl-3-(2'-chloro-4'-methoxybenzoyl)benzofuran. The subsequent demethylation, epoxy compound formation and ring opening of the epoxide to give the title compound were carried out as previously described in Examples 9 and 7.

Sources & evidence

ORD record: ord-b4212f119048415b8b7b59bbe3624ef2
Source dataset: uspto-grants-1976_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03975537

Reaction notes

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