Isopropylamine → HCID 21518646, compound

HRID 1283665Notes

Reaction equation

[OH:1][C:2]1[CH:27]=[CH:26][C:5]([C:6]([C:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[O:10][C:9]=2[C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([N+:23]([O-])=O)[CH:18]=2)=[O:7])=[CH:4][CH:3]=1.C(C1OC1)Cl.C(N)(C)C>>[NH2:23][C:19]1[CH:18]=[C:17]([C:9]2[O:10][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[C:8]=2[C:6](=[O:7])[C:5]2[CH:26]=[CH:27][C:2]([OH:1])=[CH:3][CH:4]=2)[CH:22]=[CH:21][CH:20]=1

Participants

Reactant 3

HCID 6363Isopropylamine

HCID 7835Epichlorohydrin

HCID 21518614HCID 21518614, compound

Product 1

HCID 21518646HCID 21518646, compound

Procedure

2-(3'-Aminophenyl)-3-(4'-hydroxybenzoyl)benzofuran is prepared by reduction of 3-(4'-hydroxybenzoyl)-2-(3'-nitrophenyl)benzofuran according to the procedure of Example 40. Reaction of this compound with epichlorohydrin followed by ring opening of the resultant epoxy compound with isopropylamine as previously described gives the title compound.

Sources & evidence

ORD record: ord-5fb95b50edae457fac96dfb35856d09b
Source dataset: uspto-grants-1976_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03975537

Reaction notes

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