HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-bromobenzonitrile → 3-Amino-5-bromo-1H-indazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-bromobenzonitrile | HCID 429740 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 3-Amino-5-bromo-1H-indazole | HCID 817910 | — |
Reaction Steps
Twenty grams of 4-bromo-2-cyanoaniline is treated with concentrated hydrochloric acid and sodium nitrite; the resulting diazo compound is reacted with stannous chloride in concentrated hydrochloric acid at 0° C. Working up as in Example 2 gives 3-amino-5-bromoindazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE028939 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-f7e31818a0d440dcb9d8617ebdad3d91 |
| Source note | uspto-grants-1976_08 |