反应详情

A mixture of 22 g. of 4-fluoroaniline, 50 g. of iodine, 25 g. of calcium carbonate, 75 ml. of ether and 75 ml. of water is heated at reflux for 48 hours. The ether is removed by distillation and the excess iodine is destroyed by addition of sodium thiosulfate. Steam distillation and recrystallization from petroleum ether gives 4-fluoro-2-iodoaniline.

1. additionA mixture of 22 g
2. temperatureat reflux for 48 hours
3. customThe ether is removed by distillation
4. customthe excess iodine is destroyed by addition of sodium thiosulfate
5. distillationSteam distillation and recrystallization from petroleum ether