Methyl formate → N-(5-(trifluoromethyl)-1H-indazol-3-yl)formamide

HRID 1283712Notes

Reaction equation

HRID 1283712 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]([F:14])([F:13])[F:12])[CH:9]=2)[NH:4][N:3]=1.[CH:15](OC)=[O:16]>>[CH:15]([NH:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:11]([F:12])([F:14])[F:13])[CH:9]=2)[NH:4][N:3]=1)=[O:16]

Participants

3

Reactant 2

HCID 7865Methyl formateHCID 16736Bay-H-1127

Product 1

HCID 21409159N-(5-(trifluoromethyl)-1H-indazol-3-yl)formamide

Procedure

A mixture of 5.0 g. of 3-amino-5-trifluoromethylindazole, prepared as in Example 1, and 25 ml. of methyl formate is refluxed for eight hours, then concentrated in vacuo to leave crude 3-formylamino-5-trifluoromethylindazole.

Workup

  1. additionA mixture of 5.0 g
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-b16303dcfe42434785e99c0fe796184f
Source dataset
uspto-grants-1976_08
Patent number
USRE028939

Reaction notes

Loading…