Acrylonitrile → 1-(2-Cyanoethyl)-3-hydroxy-3-phenyl-indolin-2-one

Participants

Reaction Steps

Reaction of acrylonitrile with 3-hydroxy-3-phenyl-indolin-2-one by a procedure analogous to that of Example 1 gives 1-(2-cyanoethyl)-3-hydroxy-3-phenyl-indolin-2-one Hydrogenation of the 1-(2-cyanoethyl)-3-hydroxy-3-phenyl-indolin-2-one by a procedure analogous to that of Example 2 gives 1-(3-aminopropyl)-3-hydroxy-3-phenyl-indolin-2-one. Cyclodehydration of 1-(3-aminopropyl)-3-hydroxy-3-phenylindolin-2-one by a procedure analogous to that of Example 3 gives 2,3,4,10-tetrahydro-10-phenylpyrimido [1,2-a] indol-10-ol.

Provenance & Evidence