Acrylonitrile → HCID 21516636, compound

Participants

Reaction Steps

Reaction of acrylonitrile with 3-hydroxy-3-(m-tolyl)indolin- 2-one by a procedure analogous to that of Example 1 gives 1-(2-cyanoethyl)- 3-hydroxy-3-(m-tolyl)indole- 2-one. Hydrogenation of 1-(2-cyanoethyl)-3-hydroxy-3-(m-tolyl) indolin-2-one by a procedure analogous to that of Example 2 gives 1-(3-aminopropyl)-3-hydroxy-3-(m-tolyl)indolin- 2-one. Cyclodehydration of 1-(3-aminopropyl)-3-hydroxy-3-(m-tolyl) indolin -2-one by a procedure analogous to that of Example 3 gives 2,3,4,10-tetrahydro-10-(m-tolyl) pyrimido[ 1,2-a] indol-10-ol.

Provenance & Evidence