Acrylonitrile → HCID 21516627, compound

Participants

Reaction Steps

Reaction of acrylonitrile with 3 -(m-fluorophenyl)- 3-hydroxyindolin-2-one by a procedure analogous to that of Example 1 gives 1-(2-cyanoethyl)- 3-(m-fluorophenyl)- 3-hydroxyindolin-2-one. Hydrogenation of 1-(2-cyanoethyl)- 3-(m-fluorophenyl)-3-hydroxyindolin-2-one by a procedure analogous to that of Example 2 gives 1-(3-aminopropyl)- 3-(m-fluorophenyl)-3-hydroxyindolin-2-one. Cyclodehydration of 1-(3-aminopropyl)-3-(m-fluorophenyl)-3-hydroxyindolin-2-one by a procedure analogous to that of Example 3 gives 10-(m-fluorophenyl)- 2,3,4,10-tetrahydropyrimido[ 1,2-a] indol-10-ol.

Provenance & Evidence