Acrylonitrile → HCID 21516634, compound

Participants

Reaction Steps

Reaction of acrylonitrile with 3-hydroxy-3-(m-trifluoromethylphenyl)-indolin-2-one by a process analogous to that of Example 1 gives 1-(2-cyanoethyl)-3-hydroxy-3-(m-trifluoromethylphenyl)indolin-2-one. Hydrogenation of the 1-(2-cyanoethyl)-3-hydroxy-3-(m-trifluoromethylphenyl)indolin-2-one gives 1-(3-aminopropyl)-3-hydroxy-3-(m-trifluoromethylphenyl)indolin-2-one. Cyclodehydration of 1-(3-aminopropyl)-3-hydroxy-3-(m-trifluoromethylphenyl)indolin-2-one by a procedure analogous to that of Example 3 gives 10-(m-trifluoromethylphenyl)-2,3,5,10-tetrahydropyrimido [1,2-a] indol-10-ol.

Provenance & Evidence