N-(Carbobenzyloxy)-DL-proline → HCID 21516670, compound

HRID 1283851Notes

Reaction equation

HRID 1283851 reaction equation
C1(C[O:8][C:9](=[O:34])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH:16]2[CH:20]([C:21]([OH:23])=[O:22])[CH2:19][CH2:18][N:17]2C(OCC2C=CC=CC=2)=O)C=CC=CC=1.C(N1CCCC1C(O)=O)(OC[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)=O>>[CH2:43]([O:23][C:21]([CH:20]1[CH2:19][CH2:18][NH:17][CH:16]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][C:9]([OH:8])=[O:34])=[O:22])[CH2:44][CH2:39][CH2:40][CH2:41][CH3:42]

Participants

3

Reactant 2

HCID 232388N-(Carbobenzyloxy)-DL-prolineHCID 53706586HCID 53706586, compound

Product 1

HCID 21516670HCID 21516670, compound

Procedure

By substituting 3-carboxy-1-[(phenylmethyloxy)carbonyl]-2-pyrrolidineheptanoic acid phenylmethyl ester (Example 18) for the N-carbobenzoxy-DL-proline in the procedure of Example 1, 3-[(hexyloxy)carbonyl]-2-pyrrolidineheptanoic acid is obtained.

Sources & evidence

ORD record
ord-cec6fa833f254a33af17b7ab9d4f3828
Source dataset
uspto-grants-1976_08
Patent number
US03976660

Reaction notes

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