Potassium Hydroxide → 2-tert-Butyl-4-methylphenol

HRID 1283855Notes

Reaction equation

HRID 1283855 reaction equation
[C:1]([C:5]1(C([O-])=O)[C:10]([OH:11])=[CH:9][CH:8]=[C:7]([CH3:12])[CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[K+].[OH-].[K+]>>[C:1]([C:5]1[C:10]([OH:11])=[CH:9][CH:8]=[C:7]([CH3:12])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 68145370HCID 68145370, compound

Product 1

HCID 170042-tert-Butyl-4-methylphenolYield 122.8%

Procedure

By operating according to Example 1, starting from 9.85 g of potassium 2-t-butyl-p-cresolate, obtained "in situ" by salification of 8 g of 2-t-butyl-p-cresol with KOH, and from 5.9 g of acetophenone (molar ratio = 1:1), 1.13 g of benzoylacetic acid were obtained.

Sources & evidence

ORD record
ord-d882459207dc4217a0133008c9153b55
Source dataset
uspto-grants-1976_08
Patent number
US03976677

Reaction notes

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