Acetophenone → Benzoylacetic acid

HRID 1283856Notes

Reaction equation

HRID 1283856 reaction equation
C1([C:9]([O-:11])=[O:10])C(C)=CC=CC=1O.[K+].[C:13]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)(=[O:15])[CH3:14]>>[C:13]([CH2:14][C:9]([OH:11])=[O:10])(=[O:15])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 7410AcetophenoneHCID 70420684Potassium meta cresolate

Product 1

HCID 97045Benzoylacetic acidYield 9.4%

Procedure

By operating as in Example 1, starting from 6.75 g of potassium meta-cresolate and from 5.5 g of acetophenone, 0.55 g of benzoylacetic acid were obtained.

Sources & evidence

ORD record
ord-4a035f416b864d13bd1b41db6400c8a0
Source dataset
uspto-grants-1976_08
Patent number
US03976677

Reaction notes

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