Water → HCID 13336902, compound

HRID 128386Notes

Reaction equation

HRID 128386 reaction equation
[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6](Cl)=[C:5]([CH2:12][CH3:13])[N:4]=1)#[N:2].[CH2:14]([NH:17][CH2:18][CH2:19][CH3:20])[CH2:15][CH3:16].O>CC(C)=O>[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6]([N:17]([CH2:18][CH2:19][CH3:20])[CH2:14][CH2:15][CH3:16])=[C:5]([CH2:12][CH3:13])[N:4]=1)#[N:2]

Participants

5

Reactant 3

HCID 962WaterHCID 8902DipropylamineHCID 129071995-Chloro-6-ethylpyrazine-2,3-dicarbonitrile

Product 1

HCID 13336902HCID 13336902, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2,3-Dicyano-5-chloro-6-ethylpyrazine (1.92 g; 0.01 mole) was dissolved in 30 ml of acetone. The solution was cooled to 0° to 5° C., and with stirring, 2.02 g (0.02 mole) of di-n-propylamine was added dropwise. The mixture was stirred for 30 minutes. The precipitate was separated by filtration. The filtrate was concentrated under reduced pressure to afford a yellow oily product. Water (20 ml) was added to the oily product, and the precipitated white powder was recrystallized from ethanol to afford 1.28 g (yield 50%) of 2,3-dicyano-5-di-n-propylamino-6-ethylpyrazine.

Workup

  1. temperatureThe solution was cooled to 0° to 5° C.
  2. stirringThe mixture was stirred for 30 minutes
  3. customThe precipitate was separated by filtration
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. customto afford a yellow oily product
  6. customthe precipitated white powder was recrystallized from ethanol

Sources & evidence

ORD record
ord-4e19cbcd52f644bc8a211320478bf3bc
Source dataset
uspto-grants-1981_03
Patent number
US04259489

Reaction notes

Loading…