反应详情

(1-Oxo-2-bromo-2-isopropyl-6,7-dichloro-5-indanyloxy)acetic acid (17.3 g., 0.044 mole) is dissolved in dimethyl sulfoxide (DMSO, 100 ml.) stirred under nitrogen and 1,5-diazabicyclo[4.3.0]non-5-ene (DBN) (13 g.) is added dropwise. When the exothermic reaction ceases, the mixture is stored at 20°-25°C. for 1 1/2 hours and then poured into water (1.5 l.). The precipitate is recrystallized from acetic acid-water (1:1) to afford (1-oxo-2-isopropyl-6,7-dichloroinden-5-yloxy)acetic acid (9.6 g.), m.p. 175.5°-176°C.

1. customWhen the exothermic reaction ceases
2. customis stored at 20°-25°C. for 1 1/2 hours
3. customThe precipitate is recrystallized from acetic acid-water (1:1)