2,3-Dihydroxybutanedioic Acid → (R)-Amino-phenyl-acetic acid ethyl ester

Participants

Reaction Steps

Similarly to Example 18 but using ethyl DL-phenylglycinate (5.070 g., -- contains 0.05 mole methylene chloride i.e. 27.6 mmole) and (+)-tartaric acid (4.275 g., 28.5 mmole, 1.03 equiv.) in the filtrate from a previous resolution (Example 18, 50 ml. -- made up to volume with the first and then second washes), and giving ethyl D-phenylglycinate (+)-hemitartrate solvated with 1.0 mole methanol (8.049 g., 81%), [α]D23 - 46.7° (c 2.520, H2O).

Provenance & Evidence