Cyclopentylamine → HCID 68143236, compound

HRID 1283892Notes

Reaction equation

[Cl:1][C:2]1[C:10]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:9]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:8]=[CH:7][C:3]=1[CH:4]1[O:6][CH2:5]1.[CH:27]1([NH2:32])[CH2:31][CH2:30][CH2:29][CH2:28]1>>[ClH:1].[Cl:1][C:2]1[C:10]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:9]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:8]=[CH:7][C:3]=1[CH:4]([OH:6])[CH2:5][NH:32][CH:27]1[CH2:31][CH2:30][CH2:29][CH2:28]1

Participants

Reactant 2

HCID 2906Cyclopentylamine

HCID 21516834HCID 21516834, compound

Product 1

HCID 68143236HCID 68143236, compound

Procedure

Following the procedures outlined in Example 1, the 2-chloro-3,4-dibenzyloxystyrene oxide is reacted with cyclopentylamine to give 2-chloro-α-(cyclopentylaminomethyl)-3,4-dibenzyloxybenzyl alcohol hydrochloride, m.p. 181°-182°C. Similar hydrogenation over palladium-on-carbon gives 2-chloro-α-(cyclopentylaminomethyl)-3,4-dihydroxybenzyl alcohol as an amorphous solid.

Sources & evidence

ORD record: ord-aa8dc84a34d043a0a8cd3d8349425739
Source dataset: uspto-grants-1976_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03976695

Reaction notes

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